Making PUFAs Available for Tissue Protection – Selective Phospholipase-Mediated Membrane Release of Omega-3 LCPUFA
This article at a glance
- A recent study in mice reports that human and mouse secretory group X phospholipase A2 preferentially releases omega-3 long-chain polyunsaturated fatty acids to serve anti-inflammatory and tissue-protective activities in the colon.
- Selective release of arachidonic acid by a different phospholipase, coupled to the biosynthesis of prostaglandin E2, occurs in parallel, and also contributes to the tissue-protective activity.
- Growing recognition of the involvement of distinct phospholipases in specific immunological events may one day allow us to better support their activities to drive beneficial outcomes.