DHA - Are Memories Made of This?
This article at a glance
- The hippocampal-prefrontal cortex (H-PFC) pathway is a neuronal circuit that is central to integrating working memory with contextual information, facilitating executive function, such as making decisions.
- A recent neuroscience study in the rat reports that enzymatic conversion of DHA may underlie the regulation of synaptic plasticity in the H-PFC pathway.
- Enzymatically-generated DHA-derived lipid mediators, such as resolvin D1, are suggested to function as key regulators of long-term potentiation of hippocampul input to the cortex, allowing memory formation.
- The research contributes to our understanding of how DHA supports cognitive function, providing new ideas to test mechanisms underlying circuit dysregulation in cognitive disorders.