A Multilayered Biomaterial for Vectorial Release of DHA-Derived RvD1 to Restrain Local Tissue Inflammatory Responses and Disorders
This article at a glance
- A thin, pliable, biodegradable multi-layered material incorporating the DHA-derived lipid mediator resolvin D1 (RvD1) was developed.
- The thin-film device allowed sustained diffusion of RvD1 from the surface with the lowest copolymer density, permitting one-sided release.
- RvD1 could be released from the thin-film device into arterial tissue, and activated anti-inflammatory, anti-proliferative and anti-migratory activity in smooth muscle cells.
- Thin-film devices eluting specific pro-resolving lipid mediators (SPMs), such as RvD1, may be further developed for applications in surgical and endovascular interventions to lower or resolve local inflammatory reactions and surgical complications.