Reduction in Cardiac Death Risk
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Effect of Omega-3 Dosage on Cardiovascular Outcomes: An Updated Meta-Analysis and Meta-Regression of Interventional Trials
Bernasconi AA, Wiest MM, Lavie CJ, Milani RV, Laukkanen JA
Mayo Clinic Proceedings
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Effects of Icosapent Ethyl on Total Ischemic Events: From REDUCE-IT.
Bhatt DL, Steg PG, Miller M, et al.; REDUCE-IT Investigators (2019)
J Am Coll Cardiol. 73:2791-2802.
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Omega-3 fatty acids for the primary and secondary prevention of cardiovascular disease.
Abdelhamid AS, Brown TJ, Brainard JS, et al. (2020).
Cochrane Database Syst Rev. 3(2):CD003177.
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Marine Omega-3 Supplementation and Cardiovascular Disease: An Updated Meta-Analysis of 13 Randomized Controlled Trials Involving 127 477 Participants
Hu Y, Hu FB, Manson JE (2019)
J Am Heart Assoc. 8:e013543
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Effects of n-3 Fatty Acid Supplements in Diabetes Mellitus
Bowman L, Mafham M, Wallendszus K, et al.; ASCEND Study Collaborative Group (2018)
N Engl J Med. 379:1540-1550
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Omega-3 Fatty Acid Supplementation and Cardiovascular Disease Risk: Glass Half Full or Time to Nail the Coffin Shut?
Maki KC, Dicklin MR (2018)
Nutrients. 10:E864
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Use of supplemental long-chain omega-3 fatty acids and risk for cardiac death: An updated meta-analysis and review of research gaps
Maki KC, Palacios OM, Bell M, Toth PP (2017)
J Clin Lipidol. 11:1152-60
Reduction In Coronary Heart Disease Risk
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Effect of Omega-3 Dosage on Cardiovascular Outcomes: An Updated Meta-Analysis and Meta-Regression of Interventional Trials
Bernasconi AA, Wiest MM, Lavie CJ, Milani RV, Laukkanen JA
Mayo Clinic Proceedings
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Marine n-3 Fatty Acids and Prevention of Cardiovascular Disease and Cancer
Manson JE, Cook NR, Lee IM, et al.; VITAL Research Group (2019)
N Engl J Med. 380:23-32
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A Meta-Analysis of Randomized Controlled Trials and Prospective Cohort Studies of Eicosapentaenoic and Docosahexaenoic Long-Chain Omega-3 Fatty Acids and Coronary Heart Disease Risk
Alexander DD, Miller PE, Van Elswyk ME, et al. (2017)
Mayo Clin Proc. 92:15-29
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ω-3 Polyunsaturated Fatty Acid Biomarkers and Coronary Heart Disease: Pooling Project of 19 Cohort Studies
Del Gobbo LC, Imamura F, Aslibekyan S, et al. (2016)
JAMA Intern Med. 176:1155-66
Blood Pressure Reduction
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Eicosapentaenoic acid and docosahexaenoic acid containing supplements modulate risk factors for cardiovascular disease: a meta-analysis of randomised placebo-control human clinical trials.
AbuMweis S, Jew S, Tayyem R, Agraib L (2018)
J Hum Nutr Diet. 31:67-84
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Long-chain omega-3 fatty acids eicosapentaenoic acid and docosahexaenoic acid and blood pressure: a meta-analysis of randomized controlled trials
Miller PE, Van Elswyk M, Alexander DD (2014)
Am J Hypertens. 27:885-96
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A systematic review of fish-oil supplements for the prevention and treatment of hypertension
Campbell F, Dickinson HO, Critchley JA, et al. (2013)
Eur J Prev Cardiol. 20:107–20
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Blood pressure response to fish oil supplementation: metaregression analysis of randomized trials
Geleijnse JM, Giltay EJ, Grobbee DE, et al. (2002)
J Hypertens.
Triglyceride Lowering
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Effects of Icosapent Ethyl on Total Ischemic Events: From REDUCE-IT.
Bhatt DL, Steg PG, Miller M, et al.; REDUCE-IT Investigators (2019)
J Am Coll Cardiol. 73:2791-2802.
-
Omega-3 fatty acids for the primary and secondary prevention of cardiovascular disease.
Abdelhamid AS, Brown TJ, Brainard JS, et al. (2020).
Cochrane Database Syst Rev. 3(2):CD003177.
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Long-chain omega-3 fatty acids eicosapentaenoic acid and docosahexaenoic acid dose-dependently reduce fasting serum triglycerides.
Musa-Veloso K, Binns MA, Kocenas AC, et al. (2010).
Nutr Rev. 68:155-67.
Decreased Heart Rate
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Effect of omega-3 long-chain polyunsaturated fatty acid supplementation on heart rate: a meta-analysis of randomized controlled trials
Hidayat K, Yang J, Zhang Z, et al. (2018)
Eur J Clin Nutr. 72:805-17
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The differential effects of eicosapentaenoic acid and docosahexaenoic acid on cardiometabolic risk factors: a systematic review
Innes JK, Calder PC (2018)
Int J Mol Sci. 19:pii:E532
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Eicosapentaenoic acid and docosahexaenoic acid containing supplements modulate risk factors for cardiovascular disease: a meta-analysis of randomised placebo-control human clinical trials.
AbuMweis S, Jew S, Tayyem R, Agraib L (2018)
J Hum Nutr Diet. 31:67-84
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Effect of fish oil on heart rate in humans: a meta-analysis of randomized controlled trials
Mozaffarian D, Geelen A, Brouwer IA, et al. (2005)
Circulation. 112:1945-52
Healthy Blood Vessels
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Omega-3 fatty acids supplementation improves endothelial function and arterial stiffness in hypertensive patients with hypertriglyceridemia and high cardiovascular risk
Casanova MA, Medeiros F, Trindade M, Cohen C, Oigman W, Neves MF (2017)
J Am Soc Hypertens
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Effect of fish oil supplementation on fasting vascular endothelial function in humans: a meta-analysis of randomized controlled trials
Xin W, Wei W, Li, X (2012)
PLoS One. 7:e46028
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Effect of omega-3 fatty acids supplementation on endothelial function: a meta-analysis of randomized controlled trials
Wang Q, Liang X, Wang L, et al. (2012)
Atherosclerosis. 221:536-43.
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Do long-chain n-3 fatty acids reduce arterial stiffness? A meta-analysis of randomised controlled trials
Pase MP, Grima NA, Sarris J (2011)
Br J Nutr. 106:974-80
Myocardial Infarction
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Effect of Omega-3 Dosage on Cardiovascular Outcomes: An Updated Meta-Analysis and Meta-Regression of Interventional Trials
Bernasconi AA, Wiest MM, Lavie CJ, Milani RV, Laukkanen JA
Mayo Clinic Proceedings
-
Effects of Icosapent Ethyl on Total Ischemic Events: From REDUCE-IT.
Bhatt DL, Steg PG, Miller M, et al.; REDUCE-IT Investigators (2019)
J Am Coll Cardiol. 73:2791-2802.
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Omega-3 Polyunsaturated Fatty Acids Supplementation and Cardiovascular Outcomes: Do Formulation, Dosage, and Baseline Cardiovascular Risk Matter? An Updated Meta-Analysis of Randomized Controlled Trials
Casula M, Olmastroni E, Gazzotti M, Galimberti F, Zambon A, Catapano AL.
Pharmacol Res. 2020 Jul 4:105060. Epub ahead of print.
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Marine n-3 Fatty Acids and Prevention of Cardiovascular Disease and Cancer
Manson JE, Cook NR, Lee IM, et al.; VITAL Research Group (2019)
N Engl J Med. 380:23-32
Recovery Post-MI
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Omega-3 polyunsaturated fatty acids in cardiac surgery patients: an updated systematic review and meta-analysis
Langlois PL, Hardy G, Manzanares W (2017)
Clin Nutr. 36:737-46
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Effect of omega-3 Acid ethyl esters on left ventricular remodeling after acute myocardial infarction: the OMEGA-REMODEL randomized clinical trial
Heydari B, Abdullah S, Pottala JV, et al. (2016)
Circulation. 134:378-91.
Reduction in Post-Operative Atrial Fibrillation
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N-3 polyunsaturated fatty acids for prevention of postoperative atrial fibrillation: updated meta-analysis and systematic review
Wang H, Chen J, Zhao L (2018)
J Interv Card Electrophysiol. 51:105-15.
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Omega-3 polyunsaturated fatty acids in cardiac surgery patients: an updated systematic review and meta-analysis
Langlois PL, Hardy G, Manzanares W (2017)
Clin Nutr. 36:737-46
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Prevention of postoperative atrial fibrillation in open heart surgery patients by preoperative supplementation of n-3 polyunsaturated fatty acids: an updated meta-analysis
Costanzo S, di Niro V, Di Castelnuovo A, et al. (2013)
J Thorac Cardiovasc Surg. 146:906-11.
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Efficacy and safety of omega-3 fatty acids for the prevention of atrial fibrillation: a meta-analysis
He Z, Yang L, Tian J, et al. (2013)
Can J Cardiol. 29:196-203
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Fish oil and postoperative atrial fibrillation: the Omega-3 Fatty Acids for Prevention of Post-operative Atrial Fibrillation (OPERA) randomized trial
Mozaffarian D, Marchioli R, Macchia A, et al. (2012)
JAMA. 308:2001–11