Emerging Science and Related Research

Positive Effects of DHA in Experimental Traumatic Brain Injury

Traumatic brain injury results in 53,000 deaths in the U.S. every year (Figure), with nearly twice that number suffering permanent disability, including diminished cognitive ability. Treatments with long-term benefits are few and of limited effectiveness.  Progesterone may have neurological benefits and is in a Phase III clinical trial for patients with moderate-to-severe traumatic brain injury. Attention has also turned to the potential effects of DHA in preventing and ameliorating traumatic brain and spinal cord injury. DHA involvement in neuronal membrane structure and function, learning and memory, as well as neuroplasticity…

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Eicosapentaenoic Acid and Docosahexaenoic Acid: Are They Different?

Trevor A Mori, Ph.D., Professor, School of Medicine and Pharmacology, Royal Perth Hospital Unit, University of Western Australia, Perth, Australia. Many of the cardiovascular benefits ascribed to omega-3 (n-3) fatty acids were initially attributed to eicosapentaenoic acid (EPA) rather than docosahexaenoic acid (DHA). It was suggested that some of the effects of EPA were due to its being a competitive inhibitor of arachidonic acid for the cyclooxygenase and lipoxygenase enzymes, leading to prostaglandins and leukotrienes with attenuated bioactivity compared with the respective arachidonic acid analogues. However, we now know that…

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