Fats of Life | Emerging Science and Related Research Archives

30 Jun 2018

Posted by pufa

Category Emerging Science and Related Research

High Alpha-Linolenic Acid Intake; Detrimental to DHA Status?

This article at a glance The conversion of alpha-linolenic acid (ALA) to longer chain and more desaturated omega-3 polyunsaturated fatty acids (omega-3 LCPUFA), in particular to DHA, is limited in humans consuming a Westernized diet. A recent intervention study that evaluated the effect of high ALA intake during 3 months in adults with a low baseline EPA+DHA status has observed that DHA levels in red blood cells actually decrease. Bioactive metabolites formed from DHA displayed variable temporal patterns of change in blood levels following ALA intake. This study confirms…

30 Jun 2018

Posted by pufa

Category Emerging Science and Related Research

Omega-3 Status during an American Football Playing Season

This article at a glance This is the first study that documents the status of omega-3 long-chain polyunsaturated fatty acids (omega-3 LCPUFA) in players of American Football, a sport where players receive many sub-concussive impacts over a playing season. Omega-3 LCPUFA levels decreased significantly over the course of a season. Although marked individual differences were observed, the study suggests that there is an opportunity for improvement in the monitoring and management of omega-3 status in elite athletes, with potential to influence inflammation and recovery from injury, and improve team…

30 Aug 2017

Posted by pufa

Category Clinical Conditions, Emerging Science and Related Research

The Development of Chemoresistance: A New Immune Cell-Activating Mechanism Involving Uncommon Lipids that Mediate a Stem Cell Response to Genotoxicity

This article at a glance This study identifies the omega-3 polyunsaturated fatty acid hexadecatetraenoic acid (16:4 n-3) as a ligand of GPR120, a receptor studied for its role in regulating inflammation, energy metabolism and satiety. 16:4 n-3, previously identified as a fatty acid released by mesenchymal stem cells following the exposure to platinum-containing chemotherapeutic drugs, activated GPR120 in a specific population of macrophages in the spleen. GPR120-positive splenic macrophages activated by 16:4 n-3 produced a unique lysophospholipid, lysophosphatidylcholine with esterified nervonic acid (lysoPC(24:1)), which mediated a chemoresistance response to platinum-based…

01 Mar 2017

Posted by pufa

Category Cardiovascular Health, Emerging Science and Related Research

A Multilayered Biomaterial for Vectorial Release of DHA-Derived RvD1 to Restrain Local Tissue Inflammatory Responses and Disorders

This article at a glance A thin, pliable, biodegradable multi-layered material incorporating the DHA-derived lipid mediator resolvin D1 (RvD1) was developed. The thin-film device allowed sustained diffusion of RvD1 from the surface with the lowest copolymer density, permitting one-sided release. RvD1 could be released from the thin-film device into arterial tissue, and activated anti-inflammatory, anti-proliferative and anti-migratory activity in smooth muscle cells. Thin-film devices eluting specific pro-resolving lipid mediators (SPMs), such as RvD1, may be further developed for applications in surgical and endovascular interventions to lower or resolve local inflammatory…

28 Feb 2017

Posted by pufa

Category Clinical Conditions, Emerging Science and Related Research, Guest Articles and Invited Opinion

F3-Isoprostanes and F4-Neuroprostanes: Non-enzymatic Cyclic Oxygenated Metabolites of Omega-3 Polyunsaturated Fatty Acids: Biomarkers and Bioactive Lipids

Jean-Marie Galano, Camille Oger, Valérie Bultel-Poncé, Guillaume Reversat, Alexandre Guy, Joseph Vercauteren, Claire Vigor, Thierry Durand. Institut des Biomolécules Max Mousseron (IBMM), UMR 5247, CNRS, Université de Montpellier, ENSCM, Montpellier, France. Thierry Durand Institut des Biomolécules Max Mousseron (IBMM), UMR 5247, CNRS, Université de Montpellier, ENSCM, Montpellier (France). Phone: +33 4 11 75 95 58 / Email: Thierry.Durand@umontpellier.fr Abstract: The isoprostanoids are non-enzymatic oxygenated metabolites derived from polyunsaturated fatty acids (PUFA) formed in vivo by free radical mechanism. Those cyclic oxygenated metabolites named isoprostanes (IsoPs) were originally discovered…

30 Sep 2016

Posted by pufa

Category Emerging Science and Related Research

Positive Selection of an Indel Polymorphism in the FADS Gene Cluster May be Driving Long-Chain PUFA Biosynthetic Capacity in Specific Human Populations.

This article at a glance This study reports a 22-bp nucleotide insertion-deletion (indel) genetic polymorphism that may be causally related to the control of gene expression of the fatty acid desaturases, enzymes that control the biosynthesis of long-chain polyunsaturated fatty acids (LCPUFA) from 18-carbon PUFA. The population frequency of the indel (rs66698963) is remarkably different among human populations with the insertion being far more frequent in South Asians, Africans and some East Asian populations, and far less common in European and other East Asian populations. The polymorphism has a significant…

16 Dec 2015

Posted by pufa

Category Clinical Conditions, Emerging Science and Related Research, Guest Articles and Invited Opinion

The Impact of Common Gene Variants on EPA and DHA Status and Responsiveness to Increased Intakes

Professor Anne Marie Minihane Department of Nutrition and Preventive Medicine, Norwich Medical School, University of East Anglia (UEA), Norwich, UK Website: https://www.uea.ac.uk/medicine/people/profile/a-minihane Setting the Scene A large body of human prospective epidemiology, as well as rodent feeding studies, have demonstrated the beneficial impact of the “marine” long chain n-3 PUFA (LC n-3 PUFA), EPA (20:5n-3) and DHA (22:6n-3), on fetal development, and cardiovascular and cognitive health. Randomised controlled trials (RCTs) have been less congruent, with this apparent lack of consistency likely attributable to a whole host of determinants of…

27 Aug 2012

Posted by pufa

Category Clinical Conditions, Emerging Science and Related Research, Guest Articles and Invited Opinion

ISSFAL 2012

The 10th Congress of the International Society for the Study of Fatty Acids and Lipids (ISSFAL) convened May 26-30, in Vancouver, Canada, overlooking the North Shore Mountains, Coal Harbor and Stanley Park. Three days packed with meetings, breakfast workshops, plenary and poster sessions, exhibits and a gala dinner brought together scientists and others from 33 countries. All share an interest in current research on the biochemistry, health effects and genomics of fatty acids and lipids. The conference program and abstracts can be downloaded here. Selected highlights from the meeting include:…

24 Aug 2012

Posted by pufa

Category Emerging Science and Related Research

Stepping Stones to Treating Alzheimer’s Disease: Is Insulin the Key?

Descriptions of Alzheimer’s disease, a progressive degenerative condition that robs its victims of their memory, cognitive function, language and ability to take care of themselves, centers on the accumulation of abnormal proteins amyloid-beta and tau. Amyloid-beta proteins form plaques outside the cell, while tau builds up inside the cell to form neurofibrillary tangles (Figure 1). It remains uncertain whether these abnormalities are a cause or consequence of the disease. Neither do we know what causes Alzheimer’s disease, nor can we cure it. Recently, however, there has been a great leap…

01 Dec 2011

Posted by pufa

Category Brain and Central Nervous System, Emerging Science and Related Research, Mental Health and Cognition

Is Suicide in US Military Personnel Related to Low DHA Status?

Suicide is a global problem that is more prevalent among adolescents, the elderly, war veterans and active-duty military personnel. The latter are of particular concern regarding the Iraq and Afghanistan wars, among whom suicide is the second leading cause of death (13.1%) compared with the ninth rank for the general US adult population (1.8%). Up to 2009, the number of suicides exceeded the number of combat deaths in the US military. Although a past attempted suicide is a strong predictor of suicide, other conditions, such as mental disorders, including depressive…