Clinical Conditions

Usefulness of Perioperative Omega-3 Long-Chain PUFA for Lowering Postoperative Atrial Fibrillation in Patients with Recent Myocardial Infarction

 This article at a glance This intervention study showed that perioperative supplementation with EPA/DHA to patients scheduled for coronary bypass artery grafting and who had had a recent myocardial infarction led to improved results. Specifically the authors noted development of significantly fewer incidences of post-operative atrial fibrillation, less time in intensive care, and a reduced incidence of impaired wound healing. Previous studies that had studied the effect of omega-3 LCPUFA supplementation on POAF have reported inconsistent results, possibly as a result of a lack of focus on well-defined sub-groups of patients…

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Assessing the Effectiveness of Omega-3 Long-Chain Polyunsaturated Fatty Acids in Environmental Enteropathy in Children

This article at a glance Environmental enteropathy is increasingly being recognized to contribute to nutrient malabsorption and augmented catabolism in young children living in conditions where fecal to oral contamination occurs constantly. Besides improving sanitary conditions, no effective medical interventions have been clearly identified to improve environmental enteropathy. In this study the effectiveness in environmental enteropathy of a controlled oral supplementation with multinutrients and omega-3 LCPUFA was determined in young children in a rural setting in Malawi.   Environmental enteropathy is a disease of infants and young children characterized by persistent subclinical…

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Omega-3s for Male Fertility

This article at a glance Two recent studies have addressed the role of omega-3 LCPUFA in varicocele and asthenozoospermia, two relatively common disorders of male fertility. Higher dietary intake of EPA, DHA and total omega-3 LCPUFA was found to be associated with a reduced probability to suffer asthenozoospermia. In infertile men with varicocele, the levels of EPA, DHA and total omega-3 in spermatozoa were significantly lower than in control subjects.   Male infertility has several causes including malfunctioning spermatozoa, too low spermatozoa concentrations in sperm, and physical impediments to the…

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Successful Treatment of Common Acne with 3 Months EPA/DHA

This article at a glance This is the first controlled study to address the potential effectiveness of daily EPA/DHA for common acne in young adults. The study reports — through both objective scores, and subjective assessment — decreased acne severity in young adults. The results are supported by histological analyses that signal a reduction in pilosebaceous unit inflammation. Future studies with improved masking of study subjects will be required to confirm the results.   Acne, or acne vulgaris, is a common skin disease in teenagers and young adults. It is…

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A Moderate Dose of Fish Oil: Beneficial for Drug-Resistant Partial-Onset Epilepsy

Epilepsy is a disorder of the central nervous system (CNS) in which individuals experience epileptic seizures, displays of transient deregulated neural activity in one or both hemispheres. Epileptic activity displays as changes in sensory awareness and involuntary motor activation of specific body parts, which can occur with consciousness preserved, or with loss of consciousness. Seizures can range from mild and unnoticeable to others to generalized seizures that can last several minutes or longer. The different forms and grades of severity of epilepsy may be linked to specific areas of the central…

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Higher Intake of Fish and Long-Chain Omega-3s Linked to Reduced Hearing Loss in Women

The auditory system is an important sensory system, permitting the rapid perception of sounds that reach us, helping us orient ourselves within the surroundings. Through coordination with proprioceptor and the visual systems, the auditory system also helps in fine-tuning the self-awareness and mental image of our body by hearing the relative distances of our body parts when they produce noise. Given the importance of our auditory system, the consequences of hearing loss are significant to daily life, and encompass a wide range of physical and social effects; e.g. compromised social…

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DHA and Low-Dose Aspirin, a Promising Treatment for Periodontitis

One of the most common afflictions in people is gingivitis, a mild inflammation of the gums. Uncontrolled gingivitis can lead to periodontitis, inflammation of the tissue structures underlying the gums, affecting the integrity and anchoring of the teeth. Severe periodontitis was recently reported to affect 11% of the world population and ranks among the 10 most common human diseases. Periodontitis not only affects oral health, but is now strongly suspected to also augment the risk for some systemic diseases that have an inflammatory component, such as cardiovascular disease. The main…

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The 2013 Omega-3 Fatty Acid – Prostate Cancer Debacle

William S. Harris, PhD Senior Research Scientist, Health Diagnostic Laboratory, Inc. (Richmond, VA) Professor, Department of Internal Medicine, Sanford School of Medicine, University of South Dakota President, OmegaQuant Analytics, LLC (Sioux Falls, SD)   On July 11, 2013 a paper was published online by Brasky et al. in the J Natl Cancer Institute entitled, “Plasma Phospholipid Fatty Acids and Prostate Cancer Risk in the SELECT Trial.”(1) This paper was widely publicized across all media platforms, even finding its way onto the network evening news programs. What did the study actually…

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Correcting VLDL Kinetic Abnormalities in Obesity and Insulin-Resistance

Obesity is frequently accompanied by dyslipidemia, consisting of changes in triglyceride (TG) and cholesterol levels in blood outside the ranges considered normal. Many obese subjects have significantly elevated concentrations of cholesterol incorporated in the lipoprotein particle LDL (low-density lipoprotein). Another notable change is an elevated level of the lipoprotein VLDL (very-low density lipoprotein), which carries TG and cholesterol produced in the liver to other parts of the body where these lipids can be used for energy and tissue growth. Whereas countless studies have been dedicated to understanding the potential role…

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Addressing Depression in Maintenance Hemodialysis Patients

In end-stage renal disease, over 90% of kidney function has been lost. Hemodialysis has long been a solution to prolong the life of end-stage renal disease patients. Depressive symptoms and distress are very common in chronic hemodialysis patients with end-stage renal disease, with an estimated prevalence rate of 20 to 70%. Longitudinal studies have shown that the level of depression in hemodialysis patients is variable over time, and is affected by a multitude of personal, interpersonal and nutritional factors. Episodes of depression can negatively influence nutritional status and immune function,…

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