Brain Health Studies Page

Cognitive Function       (top)

Amen DG, Harris WS, Kidd PM, et al. (2017). Quantitative Erythrocyte Omega-3 EPA Plus DHA Levels are Related to Higher Regional Cerebral Blood Flow on Brain SPECT. J Alzheimers Dis. 58:1189-99.

Dullemeijer C, Durga J, Brouwer IA, et al. (2007). n 3 fatty acid proportions in plasma and cognitive performance in older adults. Am J Clin Nutr. 86:1479-85.

Muldoon MF, Ryan CM, Sheu L, et al. (2010). Serum phospholipid docosahexaenonic acid is associated with cognitive functioning during middle adulthood. J Nutr. 140:848-53.

Pottala JV, Yaffe K, Robinson JG, et al. (2014). Higher RBC EPA + DHA corresponds with larger total brain and hippocampal volumes: WHIMS-MRI study. Neurology. 82:435-42.

Yurko-Mauro K, Alexander DD, Van Elswyk ME (2015). Docosahexaenoic acid and adult memory: a systematic review and meta-analysis. PLoS One. 10:e0120391.

Zamroziewicz MK, Paul EJ, Zwilling CE, Barbey AK (2017). Determinants of fluid intelligence in healthy aging: Omega-3 polyunsaturated fatty acid status and frontoparietal cortex structure. Nutr Neurosci. 11:1-10.

Zhang Y, Chen J, Qiu J, et al. (2016). Intakes of fish and polyunsaturated fatty acids and mild-to-severe cognitive impairment risks: a dose-response meta-analysis of 21 cohort studies. Am J Clin Nutr. 103:330-40.

Mental Health    (top)

Buydens-Branchey L, Branchey M, Hibbeln JR (2008). Associations between increases in plasma n-3 polyunsaturated fatty acids following supplementation and decreases in anger and anxiety in substance abusers. Prog Neuropsychopharmacol Biol Psychiatry. 32:568-75.

Freeman MP, Hibbeln JR, Wisner KL, et al. (2006). Omega-3 fatty acids: evidence basis for treatment and future research in psychiatry. J Clin Psychiatry. 67:1954-67.

Hallahan B, Ryan T, Hibbeln JR, et al. (2016). Efficacy of omega-3 highly unsaturated fatty acids in the treatment of depression. Br J Psychiatry. 209:192-201.

Kiecolt-Glaser JK, Belury MA, Andridge R, et al. (2011). Omega-3 supplementation lowers inflammation and anxiety in medical students: a randomized controlled trial. Brain Behav Immun. 25:1725-1734.

Liu JJ, Galfalvy HC, Cooper TB, et al. (2013). Omega-3 polyunsaturated fatty acid (PUFA) status in major depressive disorder with comorbid anxiety disorders. J Clin Psychiatry. 74:732-8.

Lin PY, Huang SY, Su KP (2010). A meta-analytic review of polyunsaturated fatty acid compositions in patients with depression. Biol Psychiatry. 68:140-7.

Lin PY, Mischoulon D, Freeman MP, et al. (2012). Are omega-3 fatty acids antidepressants or just mood-improving agents? The effect depends upon diagnosis, supplement preparation, and severity of depression. Mol Psychiatry. 17:1161-3.

Mocking RJ, Harmsen I, Assies J, et al. (2016). Meta-analysis and meta-regression of omega-3 polyunsaturated fatty acid supplementation for major depressive disorder. Transl Psychiatry. 6:e756.

Su KP, Tseng PT, Lin PY, et al. (2018). Association of use of omega-3 polyunsaturated fatty acids with changes in severity of anxiety symptoms: A systematic review and meta-analysis. JAMA Network Open. 1(5):e182327.

Sublette ME, Ellis SP, Geant AL, Mann JJ (2011). Meta-analysis of the effects of eicosapentaenoic acid (EPA) in clinical trials in depression. J Clin Psychiatry. 72:1577-84.

Zanarini MC, Frankenburg FR (2003). Omega-3 fatty acid treatment of women with borderline personality disorder: a double-blind, placebo-controlled pilot study. Am J Psychiatry. 160:167-9.

ADHD/Learning         (top)

Bloch MH, Qawasmi A (2011). Omega-3 fatty acid supplementation for the treatment of children with attention-deficit/hyperactivity disorder symptomatology: systematic review and meta-analysis. J Am Acad Child Adolesc Psychiatry 50:991-1000.

Chang JP, Su KP, Mondelli V, Pariante CM (2018). Omega-3 Polyunsaturated Fatty Acids in Youths with Attention Deficit Hyperactivity Disorder: a Systematic Review and Meta-Analysis of Clinical Trials and Biological Studies. Neuropsychopharmacology. 43:534-45.

Gow RV, Hibbeln JR, Parletta N (2015). Current evidence and future directions for research with omega-3 fatty acids and attention deficit hyperactivity disorder. Curr Opin Clin Nutr Metab Care. 18:133-8.

Gow RV, Vallee-Tourangeau F, Crawford MA, et al (2013). Omega-3 fatty acids are inversely related to callous and unemotional traits in adolescent boys with attention deficit hyperactivity disorder. Prostaglandins Leukot Essent Fatty Acids. 88:411-8.

Hawkey E, Nigg JT (2014). Omega-3 fatty acid and ADHD: blood level analysis and meta-analytic extension of supplementation trials. Clin Psychol Rev. 34:496-505.

Vesco AT, Young AS, Arnold LE, Fristad MA (2018). Omega-3 supplementation associated with improved parent-rated executive function in youth with mood disorders: secondary analyses of the omega 3 and therapy (OATS) trials. J Child Psychol Psychiatry. 59:628-636.

Yonezawa K, Nonaka S, Iwakura Y, et al. (Epub ahead of print 2018 June 20). Investigation into the plasma concentration of ω3 polyunsaturated fatty acids in Japanese attention-deficit hyperactivity disorder patients. J Neural Transm (Vienna).

Traumatic Brain Injury      (top)

Bailes JE, Mills J (2010). Docosahexaenoic acid reduces traumatic axonal injury in a rodent head injury model. J Neurotrauma. 27:1617-24.

Bailes JE, Patel V (2014). The potential for DHA to mitigate mild traumatic brain injury. Mil Med. 179:112-6.

Butt CM, Harrison JL, Rowe RK, et al. (2017). Selective reduction of brain docosahexaenoic acid after experimental brain injury and mitigation of neuroinflammatory outcomes with dietary DHA. Curr Res Concussion.  4:e38–e54.

Desai A, Kevala K, Kim HY (2014). Depletion of brain docosahexaenoic acid impairs recovery from traumatic brain injury. PLoS One. 9(1):e86472.

Lewis M, Ghassemi P, Hibbeln J (2013). Therapeutic use of omega-3 fatty acids in severe head trauma. Am J Emerg Med. 31:273.e5-8.

Michael-Titus AT, Priestley JV (2014). Omega-3 fatty acids and traumatic neurological injury: from neuroprotection to neuroplasticity? Trends Neurosci. 37:30-8.

Mills JD, Hadley K, Bailes JE (2011). Dietary supplementation with the omega-3 fatty acid docosahexaenoic acid in traumatic brain injury? Neurosurgery. 68:474-81.

Oliver JM, Jones MT, Kirk KM, et al. (2016). Effect of Docosahexaenoic Acid on a Biomarker of Head Trauma in American Football. Med Sci Sports Exerc. 48:974-82.

Roberts L, Bailes J, Dedhia H, et al. (2008). Surviving a mine explosion. J Am Coll Surg. 207:276-283.

Schober ME, Requena DF, Abdullah OM, et al. (2016). Dietary Docosahexaenoic Acid Improves Cognitive Function, Tissue Sparing, and Magnetic Resonance Imaging Indices of Edema and White Matter Injury in the Immature Rat after Traumatic Brain Injury. J Neurotrauma. 33:390-402.

Tyagi E, Agrawal R, Zhuang Y, et al. (2013). Vulnerability imposed by diet and brain trauma for anxiety-like phenotype: implications for post-traumatic stress disorders. PLoS One. 8(3):e57945.

Wu A, Ying Z, Gomez-Pinilla F (2004). Dietary omega-3 fatty acids normalize BDNF levels, reduce oxidative damage, and counteract learning disability after traumatic brain injury in rats. J Neurotrauma. 21:1457–67.

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