A Multilayered Biomaterial for Vectorial Release of DHA-Derived RvD1 to Restrain Local Tissue Inflammatory Responses and Disorders

This article at a glance A thin, pliable, biodegradable multi-layered material incorporating the DHA-derived lipid mediator resolvin D1 (RvD1) was developed. The thin-film device allowed sustained diffusion of RvD1 from the surface with the lowest copolymer density, permitting one-sided release. RvD1 could be released from the thin-film device into arterial tissue, and activated anti-inflammatory, anti-proliferative

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Positive Selection of an Indel Polymorphism in the FADS Gene Cluster May be Driving Long-Chain PUFA Biosynthetic Capacity in Specific Human Populations.

This article at a glance This study reports a 22-bp nucleotide insertion-deletion (indel) genetic polymorphism that may be causally related to the control of gene expression of the fatty acid desaturases, enzymes that control the biosynthesis of long-chain polyunsaturated fatty acids (LCPUFA) from 18-carbon PUFA. The population frequency of the indel (rs66698963) is remarkably different

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