The Development of Chemoresistance: A New Immune Cell-Activating Mechanism Involving Uncommon Lipids that Mediate a Stem Cell Response to Genotoxicity

This article at a glance This study identifies the omega-3 polyunsaturated fatty acid hexadecatetraenoic acid (16:4 n-3) as a ligand of GPR120, a receptor studied for its role in regulating inflammation, energy metabolism and satiety. 16:4 n-3, previously identified as a fatty acid released by mesenchymal stem cells following the exposure to platinum-containing chemotherapeutic drugs,

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The Impact of Omega-3 LCPUFA on Colorectal Cancer Development Guides Clinical Research towards Considering Immune Modulation and Regulation of Genomic Stability

This article at a glance In adults that develop colorectal cancer, survival is increased if omega-3 LCPUFA intake is modestly increased after diagnosis. Large prospective cohort studies tracked colorectal cancer incidence and assessed genomic stability and immune cell composition of tumors in relation to dietary intake of omega-3 long-chain polyunsaturated fatty acids (omega-3 LCPUFA). The

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Making PUFAs Available for Tissue Protection – Selective Phospholipase-Mediated Membrane Release of Omega-3 LCPUFA

This article at a glance A recent study in mice reports that human and mouse secretory group X phospholipase A2 preferentially releases omega-3 long-chain polyunsaturated fatty acids to serve anti-inflammatory and tissue-protective activities in the colon. Selective release of arachidonic acid by a different phospholipase, coupled to the biosynthesis of prostaglandin E2, occurs in parallel, and

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Short-term Perioperative EPA/DHA Supplementation for Immune Modulation and Long-term Outcome; New Developments

This article at a glance Three recent studies have looked at different aspects of early post-surgical immune-modulatory effects of perioperative supplementation with EPA/DHA. These include lowered neutrophil activation potential, a decreased neutrophil-to-lymphocyte ratio, and reduced need for antibiotics. Short-term supplementation may lead to long-term benefits that had not been recognized previously, and that merit further

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EPA for Remission of Autoimmune Small-Vessel Vasculitis

This article at a glance In two clinical cases, EPA was recognized to possibly offer support to the long-term remission of autoimmune small vessel vasculitis, when used in combination with methylprednisolone and aspirin. The study next addressed the mechanisms whereby this may occur. A potential role for EPA as an adjunct to drug treatment for

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Circulating Specialized Proresolving Lipid Mediators after Short-term EPA/DHA-Supplementation

This article at a glance This study addressed the levels of anti-inflammatory and resolution-promoting lipid mediators derived from EPA and DHA in human plasma during oral supplementation with EPA/DHA over a relatively short period of five days. The potential effect of aspirin on the selective formation of stereoisomers of several derivatives was also assessed. The results

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Reference Profiles for PUFA-derived Lipid Mediators in Human Plasma and Serum

The long chain polyunsaturated fatty acids (PUFA) arachidonic acid (AA), eicosapentaenoic acid (EPA), and docosahexaenoic acid (DHA) are used by the body to produce lipid mediators, which are derivatives with a variety of functions including regulating inflammatory responses, while protecting tissues against inflammatory insult and infection. AA, EPA and DHA are substrates for enzymatic reactions

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DHA in Pregnancy Not Linked to Atopic Diseases in High-Risk Children at Age 3

There are many plausible reasons to think that increased consumption of long-chain omega-3 PUFAs (n-3 LC-PUFAs) during pregnancy or infancy may reduce the development of atopic allergic diseases, such as eczema, wheeze and rhinitis. These allergies in infants and children are characterized by the increased production of immunoglobulin E (IgE), a class of antibody capable

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