Antimicrobial Defense Linked to the Hemostatic Response

This article at a glance This study reports that the coagulation of blood leads to the formation of arachidonic acid (AA)-, eicosapentaenoic acid (EPA)- and docosahexaenoic acid (DHA)-derived specialized proresolving mediators (SPMs) that promote microbial clearance. Clotting of human whole blood led to the formation of a distinct cluster of SPMs, namely lipoxin B4, resolvin

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The Effect of Macronutrient Composition on Endogenous Long-Chain Polyunsaturated Fatty Acid Status during Weight Loss

This article at a glance The influence on tissue fatty acid composition of three different isocaloric diets  containing carbohydrates with a low glycemic index, carbohydrates with a high glycemic index, or a reduced fat content, respectively, was assessed in overweight-obese adults on a 500 kcal/d-energy restriction in a randomized controlled intervention trial. The study had

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Guidelines and EPA+DHA: Irreconcilable?

  Prof. Dr. C. von Schacky, Preventive Cardiology, Med Clinic I, University of Munich, and Omegametrix, Martinsried, both Germany. Email: Clemens.vonSchacky@med.uni-muenchen.de   Cardiac societies, like the American Heart Association (AHA) or the European Society of Cardiology (ESC), periodically publish guidelines, among them on primary or secondary prevention of cardiovascular disease (AHA) or cardiovascular prevention (ESC)

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Omega-3 LCPUFA Intake-Induced Molecular Changes in Type 2 Diabetes

This article at a glance The effects of omega-3 long-chain polyunsaturated fatty acids (LCPUFA) on deranged glucose homeostasis in type 2 diabetics are incompletely understood. Metabolomic analyses of blood samples from two recent randomized controlled clinical trials in American and Chinese adults with type 2 diabetes link omega-3 LCPUFA supplementation to changes in branched-chain amino

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Enhancing Breast Cancer Treatment with Omega-3 Fatty Acids

Miranda Brun, PhD and Catherine J. Field, PhD RD Department of Agricultural, Food and Nutritional Science University of Alberta, Edmonton, Alberta, Canada   In North America and Europe, breast cancer accounts for over 25% of all new cancer diagnoses in women, and approximately 1 in 8 women will be diagnosed with breast cancer in their

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F3-Isoprostanes and F4-Neuroprostanes: Non-enzymatic Cyclic Oxygenated Metabolites of Omega-3 Polyunsaturated Fatty Acids: Biomarkers and Bioactive Lipids

Jean-Marie Galano, Camille Oger, Valérie Bultel-Poncé, Guillaume Reversat, Alexandre Guy, Joseph Vercauteren, Claire Vigor, Thierry Durand. Institut des Biomolécules Max Mousseron (IBMM), UMR 5247, CNRS, Université de Montpellier, ENSCM, Montpellier, France.   Thierry Durand Institut des Biomolécules Max Mousseron (IBMM), UMR 5247, CNRS, Université de Montpellier, ENSCM, Montpellier (France). Phone: +33 4 11 75 95

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Indications for an Association between Higher PUFA Intake with Improved Lean Mass and Reduced Adiposity in Children

This article at a glance This study addressed if any associations exist between self-reported dietary intake of polyunsaturated fatty acids and obesity in 7-12 year old US American children from a racially diverse background. Associations were identified between higher total PUFA intake and lower body fat and intra-abdominal adipose tissue. Total dietary PUFA intake, as

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No Change in Upper Gastrointestinal Complications from Low-Dose Aspirin with Concurrent Prescription Omega-3 Fatty Acid Intake

This article at a glance This study assessed if in a large group of patients taking low-dose aspirin for thromboprophylactic purposes during their otherwise daily life, the concurrent use of prescription omega-3 fatty acids would affect the incidence of upper-gastrointestinal complications. Drawing from a large patient register, the authors determined that concurrent use of low-dose

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Sustaining DHA Accretion during Recovery from Acute Malnutrition with Improvements in Ready-to-Use-Therapeutic Foods

This article at a glance Two recent studes have explored the possibility of adjusting the fatty acid composition of Ready-to-Use Therapeutic Foods (RUTF) that are used to rehabilitate malnourished children, with the aim of better supporting omega-3 LCPUFA status. DHA levels drop during the recovery of malnourished children treated with a standard RUTF – this

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