The RvD1/LTB4 Ratio in Saliva – Assessing the Usefulness of an Innovative Biomarker for the Resolution of Inflammation in Vascular Disease.

This article at a glance The potential utility of the ratio of resolvin D1 (RvD1), a pro-resolving lipid mediator derived from DHA, to leukotriene B4 (LTB4), a pro-inflammatory mediator derived from AA, in saliva was determined to predict the level of non-resolving vascular inflammation. The study reports that patients with a higher carotid intima-media thickness

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Evaluating the Value of Stratification on Omega-3 LCPUFA Levels when the Randomized Controlled Testing Methodology is not Sufficiently Well-Controlled

This article at a glance This pilot study evaluated the concept that stratification of study participants can be useful for improving interpretations of the relationship between long-chain polyunsaturated fatty acid (LCPUFA) intake and biological effect. In patients scheduled for coronary artery bypass graft and/or heart valve replacement surgery, one group of individuals randomly assigned to

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Evaluating the Formation of Non-Enzymatic Oxidation Products of EPA and AA in a Population at Risk for Omega-3 Long-Chain Polyunsaturated Fatty Acid Deficiency

This article at a glance This study addressed the relationship between omega-3 status in the Inuit and the plasma levels of omega-3 LCPUFA-derived isoprostanes. EPA-derived isoprostane levels were positively related to omega-3 fatty acid status, and unrelated to cardiometabolic risk factors, unlike isoprostanes derived from arachidonic acid. Older Inuit that adhere more strongly to traditional

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Gaining Insight into the Relative Contributions of EPA and DHA to Lowering the Risk for Atherothrombotic Disease Incidence

This article at a glance Two recent studies have assessed whether either EPA or DHA may be more closely associated to markers of risk for the development and incidence of atherosclerotic disease. In elderly Japanese patients at high risk for acute atherothrombotic complications, the serum EPA level was associated with a lower incidence of plaque

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Adequate Dietary Intake of Omega-3 LCPUFA by People Aged 55-80 Years is Associated with a Markedly Reduced Risk of Death from Cardiovascular and Coronary Heart Disease in the Context of a Mediterranean Diet

This article at a glance This study has examined the relationship between ALA and omega-3 LCPUFA intake, and the risk of developing cardiovascular disease and death in older adults. People who were at known risk of developing cardiovascular disease and that met international recommended intake levels of ALA (≥0.7 en%) and omega-3 LCPUFA (≥500 mg/d

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Higher Total Omega-3 Intake is Associated with Less Vascular Calcification in Older Women

This article at a glance Calcification of the abdominal aorta is a predictor of cardiovascular disease (CVD), independent of other CVD risk factors. This study addressed whether vascular calcification development in adults followed over an 18-year period displays a relation to dietary intake of omega-3 polyunsaturated fatty acids. The study reports that higher alpha-linolenic acid

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The Influence of Omega-3 LCPUFA Supplementation on Cardio-Respiratory Function during Exercise in Endurance Athletes

This article at a glance How specific nutrients modulate adaptations to exercise and endurance training is a topic of growing interest. Two recent small studies have made a careful analysis of potential cardio-respiratory changes in response to omega-3 LCPUFA supplementation in highly-trained athletes at rest, during exercise, and during recovery. The results suggest that specific

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Cardio-Protective Effects of Omega-3 LCPUFA in Percutaneous Coronary Intervention Reperfusion Therapy after ST-Segment Elevation Acute Myocardial Infarction

This article at a glance Acute myocardial infarction (AMI) remains one of the most common causes of death globally. The study reports the results of an observational study of Japanese patients who had a STEMI-type AMI and that received percutaneous coronary intervention (PCI) reperfusion therapy. The results indicate that people who had EPA + DHA

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