The Relation between Individual Polyunsaturated Fatty Acids and Atherosclerosis Development

This article at a glance This prospective multi-ethnic cohort study has examined the relationships between various polyunsaturated fatty acids in plasma phospholipids with the development of  atherosclerosis over a 10 year period in adults that were free of cardiovascular disease at baseline. The study reports – using vascular imaging techniques – that the level of

Read more...

The RvD1/LTB4 Ratio in Saliva – Assessing the Usefulness of an Innovative Biomarker for the Resolution of Inflammation in Vascular Disease.

This article at a glance The potential utility of the ratio of resolvin D1 (RvD1), a pro-resolving lipid mediator derived from DHA, to leukotriene B4 (LTB4), a pro-inflammatory mediator derived from AA, in saliva was determined to predict the level of non-resolving vascular inflammation. The study reports that patients with a higher carotid intima-media thickness

Read more...

Guidelines and EPA+DHA: Irreconcilable?

  Prof. Dr. C. von Schacky, Preventive Cardiology, Med Clinic I, University of Munich, and Omegametrix, Martinsried, both Germany. Email: Clemens.vonSchacky@med.uni-muenchen.de   Cardiac societies, like the American Heart Association (AHA) or the European Society of Cardiology (ESC), periodically publish guidelines, among them on primary or secondary prevention of cardiovascular disease (AHA) or cardiovascular prevention (ESC)

Read more...

Evaluating the Value of Stratification on Omega-3 LCPUFA Levels when the Randomized Controlled Testing Methodology is not Sufficiently Well-Controlled

This article at a glance This pilot study evaluated the concept that stratification of study participants can be useful for improving interpretations of the relationship between long-chain polyunsaturated fatty acid (LCPUFA) intake and biological effect. In patients scheduled for coronary artery bypass graft and/or heart valve replacement surgery, one group of individuals randomly assigned to

Read more...

Evaluating the Formation of Non-Enzymatic Oxidation Products of EPA and AA in a Population at Risk for Omega-3 Long-Chain Polyunsaturated Fatty Acid Deficiency

This article at a glance This study addressed the relationship between omega-3 status in the Inuit and the plasma levels of omega-3 LCPUFA-derived isoprostanes. EPA-derived isoprostane levels were positively related to omega-3 fatty acid status, and unrelated to cardiometabolic risk factors, unlike isoprostanes derived from arachidonic acid. Older Inuit that adhere more strongly to traditional

Read more...

Gaining Insight into the Relative Contributions of EPA and DHA to Lowering the Risk for Atherothrombotic Disease Incidence

This article at a glance Two recent studies have assessed whether either EPA or DHA may be more closely associated to markers of risk for the development and incidence of atherosclerotic disease. In elderly Japanese patients at high risk for acute atherothrombotic complications, the serum EPA level was associated with a lower incidence of plaque

Read more...

Adequate Dietary Intake of Omega-3 LCPUFA by People Aged 55-80 Years is Associated with a Markedly Reduced Risk of Death from Cardiovascular and Coronary Heart Disease in the Context of a Mediterranean Diet

This article at a glance This study has examined the relationship between ALA and omega-3 LCPUFA intake, and the risk of developing cardiovascular disease and death in older adults. People who were at known risk of developing cardiovascular disease and that met international recommended intake levels of ALA (≥0.7 en%) and omega-3 LCPUFA (≥500 mg/d

Read more...