The Effect of Macronutrient Composition on Endogenous Long-Chain Polyunsaturated Fatty Acid Status during Weight Loss

This article at a glance The influence on tissue fatty acid composition of three different isocaloric diets  containing carbohydrates with a low glycemic index, carbohydrates with a high glycemic index, or a reduced fat content, respectively, was assessed in overweight-obese adults on a 500 kcal/d-energy restriction in a randomized controlled intervention trial. The study had

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The Development of Chemoresistance: A New Immune Cell-Activating Mechanism Involving Uncommon Lipids that Mediate a Stem Cell Response to Genotoxicity

This article at a glance This study identifies the omega-3 polyunsaturated fatty acid hexadecatetraenoic acid (16:4 n-3) as a ligand of GPR120, a receptor studied for its role in regulating inflammation, energy metabolism and satiety. 16:4 n-3, previously identified as a fatty acid released by mesenchymal stem cells following the exposure to platinum-containing chemotherapeutic drugs,

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The RvD1/LTB4 Ratio in Saliva – Assessing the Usefulness of an Innovative Biomarker for the Resolution of Inflammation in Vascular Disease.

This article at a glance The potential utility of the ratio of resolvin D1 (RvD1), a pro-resolving lipid mediator derived from DHA, to leukotriene B4 (LTB4), a pro-inflammatory mediator derived from AA, in saliva was determined to predict the level of non-resolving vascular inflammation. The study reports that patients with a higher carotid intima-media thickness

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Confidence in Science

Dear reader of Fats of Life, In case you’ve been having doubts about keeping the faith in science, this issue of Fats of Life will help you revive your confidence that science keeps advancing in healthy directions. New findings in biology and medicine keep occurring while we all try to stay oriented in the information

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Guidelines and EPA+DHA: Irreconcilable?

  Prof. Dr. C. von Schacky, Preventive Cardiology, Med Clinic I, University of Munich, and Omegametrix, Martinsried, both Germany. Email: Clemens.vonSchacky@med.uni-muenchen.de   Cardiac societies, like the American Heart Association (AHA) or the European Society of Cardiology (ESC), periodically publish guidelines, among them on primary or secondary prevention of cardiovascular disease (AHA) or cardiovascular prevention (ESC)

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Evaluating the Value of Stratification on Omega-3 LCPUFA Levels when the Randomized Controlled Testing Methodology is not Sufficiently Well-Controlled

This article at a glance This pilot study evaluated the concept that stratification of study participants can be useful for improving interpretations of the relationship between long-chain polyunsaturated fatty acid (LCPUFA) intake and biological effect. In patients scheduled for coronary artery bypass graft and/or heart valve replacement surgery, one group of individuals randomly assigned to

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Maternal Plasma Docosahexaenoic Acid (DHA) Concentrations Increase at the Critical Time of Neural Tube Closure

  Barbara J Meyer (University of Wollongong, Australia) Dilys J Freeman (University of Glasgow, UK)   Docosahexaenoic acid (DHA) and polyunsaturated fatty acid (PUFA) metabolism DHA is an omega-3 long chain polyunsaturated fatty acid (n-3 LCPUFA) containing 22 carbons and 6 carbon to carbon double bonds denoted as 22:6n-3. It is an n-3 fatty acid

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Look What’s New at Fats of Life

Dear Reader of Fats of Life. Welcome to 2017 and a new issue of Fats of Life, which brings exciting changes in our design. First of all, we have renamed the PUFA Newsletter to Fats of Life Newsletter, a change that had been pending for some time. We wanted to continue with the name “Fats

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Evaluating the Formation of Non-Enzymatic Oxidation Products of EPA and AA in a Population at Risk for Omega-3 Long-Chain Polyunsaturated Fatty Acid Deficiency

This article at a glance This study addressed the relationship between omega-3 status in the Inuit and the plasma levels of omega-3 LCPUFA-derived isoprostanes. EPA-derived isoprostane levels were positively related to omega-3 fatty acid status, and unrelated to cardiometabolic risk factors, unlike isoprostanes derived from arachidonic acid. Older Inuit that adhere more strongly to traditional

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Bronchopulmonary Dysplasia in Preterm Infants – Understanding the Physiological Changes in AA and DHA during Gestation

This article at a glance Bronchopulmonary dysplasia is a form of lung injury caused by assisted ventilation and oxygen support compounding an incomplete development of lung tissue observed in very early and low birth weight preterm infants. In a study of fetal fatty acid (LCPUFA) accretion during the third trimester of pregnancy, the level of

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