New Views

Dear reader, In this issue of the Fats of Life Newsletter we highlight several new studies on polyunsaturated fatty acids. We first take a look at a long-lasting observational study that inform us on the relationships between specific fatty acids and the development of atherosclerosis, a slow process that is difficult to study in humans

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The Relation between Individual Polyunsaturated Fatty Acids and Atherosclerosis Development

This article at a glance This prospective multi-ethnic cohort study has examined the relationships between various polyunsaturated fatty acids in plasma phospholipids with the development of  atherosclerosis over a 10 year period in adults that were free of cardiovascular disease at baseline. The study reports – using vascular imaging techniques – that the level of

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Modulation by Docosahexaenoic Acid of a Novel Potential Biomarker of Cognitive Decline

This article at a glance Prevention of Alzheimer’s disease by intervention at earlier stages of cognitive decline is increasingly viewed as an alternative approach to the not yet achieved successful treatment of Alzheimer’s disease. This exploratory study makes a preliminary evaluation of neuronal pentraxin 1 (NP1) as a new biomarker of cognitive decline, that reflects

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Gaining Control over Physical Aggression

This article at a glance A recent, carefully controlled study, has investigated whether daily supplementation with EPA/DHA could attenuate physical aggresion. The study reports an important reduction in the level of self-reported physical aggression. The World Health Organization defines intentional injuries as largely preventable events resulting from aggression and violence. Interpersonal violence-related mortality includes deaths

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Omega-3 LCPUFA Chemical Oxidation Pathways Associated with Cognitive Disorders

This article at a glance Neuroprostanes are oxidation products of DHA that are produced endogenously via non-enzymatic pathways. The chemical structure and biological activity has only been characterized for some of the neuroprostanes. This study reports that two neuroprostanes, 4-F4t-NeuroP and 10-F4t-NeuroP, are found at elevated levels in patients with multiple scleroris, Down syndrome, Rett

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New Insight into the Retinopathy of Prematurity

This article at a glance A recent intervention study that evaluated the usefulness of supplementing the parenteral feed of premature babies with long-chain omega-3 fatty acids to alleviate the retinopathy frequently associated with premature birth was unsuccesful. An assessment of the fatty acid levels in the prematurely-born babies now indicates that low levels of arachidonic

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Omega-3 Status during an American Football Playing Season

This article at a glance This is the first study that documents the status of omega-3 long-chain polyunsaturated fatty acids (omega-3 LCPUFA) in players of American Football, a sport where players receive many sub-concussive impacts over a playing season. Omega-3 LCPUFA levels decreased significantly over the course of a season. Although marked individual differences were

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