Adina Michael-Titus is a pharmacologist and neuroscientist who is a professor of neuroscience at Barts and the London School of Medicine and Dentistry, Queen Mary College, University of London. She is currently lead of the neurotrauma and neurodegeneration group in the Centre for Neuroscience and Trauma. She also holds the positions of director of graduate studies at the Centre and program director of a MSc in neuroscience and translational medicine, whose main aim is to help train the next generation of scientists and physicians involved in the clinical translation of discoveries in neuroscience. She is an inventor on several patents and regularly acts as a reviewer for international research organizations and for UK research councils.
Michael-Titus was awarded a doctorate in sciences in France for studies on novel inhibitors of opioid peptide-degrading enzymes. After post-doctoral studies in Rouen and Paris, she moved to London as lecturer in physiology and pharmacology. Between 2002 and 2004, she spent sabbatical research time as a senior scientist and head of section at the pharmaceutical company Lundbeck A/S in Copenhagen. Her research has covered various topics including: peptidergic systems and the co-release of active peptides and their metabolites, excitatory amino acid transmission and the pathogenesis of depression, new models of schizophrenia, and more recently, neuroprotection. After her return to academic research in London, she developed a program of studies on neuroprotection in spinal cord injury. Her recent work demonstrates that omega-3 polyunsaturated fatty acids have a significant therapeutic potential in traumatic spinal cord injury. Currently she is coordinating a series of projects on new drug targets in neurotrauma and has also recently initiated a large translational project on new metal-binding compounds for the treatment of Alzheimer’s disease.
Michael-Titus co-authored The Nervous System, 2nd Ed., Churchill Livingstone Elsevier, London, 2010.
Selected recent publications:
King VR Huang WL, Dyall SC, Curran OE, Priestley JV, Michael-Titus AT. Omega-3 fatty acids improve recovery, whereas omega-6 fatty acids worsen outcome, after spinal cord injury in the adult rat. J Neurosci 2006;26:4672-4680.
Dyall SC, Michael GJ, Whelpton R, Scott AG, Michael-Titus AT. Dietary enrichment with omega-3 polyunsaturated fatty acids reverses age-related decreases in the GluR2 and NR2B glutamate receptor subunits in rat forebrain. Neurobiol Aging 2007;28,424-439.
Huang WL, King VR, Curran OE, Dyall SC, Ward RE, Lal N, Priestley JV, Michael-Titus AT. A combination of intravenous and dietary docosahexaenoic acid significantly improves outcome after spinal cord injury. Brain 2007;130:3004-3019.
GMichael-Titus AT. Omega-3 fatty acids and neurological injury. Prostaglandins Leukotr Essent Fatty Acids 2007;77:295-300.
Malaspina A, Michael-Titus AT. Is the modulation of retinoid and retinoid-associated signaling a future therapeutic strategy in neurological trauma and neurodegeneration? J Neurochem 2008;104:584-595.
Dyall SC Michael-Titus AT. Neurological benefits of omega-3 fatty acids. Neuromolecular Med 2008;10;219-235.
Glaser C, Demmelmair H, Sausenthaler S, Herbarth O, Heinrich J, Koletzko B. Fatty acid composition of serum glycerophospholipids in children. J Pediatr 2010;157:826-831.
Huang W, Bhavsar A, Ward RE, Hall JC, Priestley JV, Michael-Titus AT. Arachidonyl trifluoromethylketone is neuroprotective after spinal cord injury. J Neurotrauma 2009;26:1429-34.
Robson LG, Dyall S, Sidloff D, Michael-Titus AT. Omega-3 polyunsaturated fatty acids increase the neurite outgrowth of rat sensory neurones throughout development and in aged animals. Neurobiol Aging 2010;31:678-87.
Dyall SC, Michael, GJ, Michael-Titus AT. Omega-3 fatty acids reverse age-related decreases in nuclear receptors and increase neurogenesis in old rats. J Neurosci Res 2010;88:2091-20102.
Ward RE, Huang W, Curran OE, Priestley JV, Michael-Titus AT. Docosahexaenoic acid prevents white matter damage following spinal cord injury. J Neurotrauma 2010;27;1769-1780.